BackgroundAlthough a large number of clinical trials on interventions demonstrating efficacy (or lack thereof) are conducted annually, much of this evidence is not accessible to scientists and clinicians.ObjectivesWe aimed to determine the publication rate of posttraumatic stress disorder (PTSD) trials that have been registered in clinical trial registries, and the factors associated with publication.MethodsTrials, completed on January 15, 2015, were identified via the US National Institutes of Health clinical trials registry, the European Union Clinical Trials Register and the WHO International (...) Clinical Trials Registry Platform. A systematic search for publications (published by the end of March 2018) related to each of the registered trials were then performed.ResultsFour hundred and thirty-eight of 1982 potentially eligible trials were included. Only 34% of interventional trials were registered prior to initiation, 9% were registered within 2 months of starting and 20% after trial completion. Of the 438 included trials, 72% had generated peer-reviewed publications, while an additional 7% had disseminated results in some other form (such as on the trial database), 26 months after trial completion. Randomisation of a trial was the only factor individually associated with publication, in logistic regression analysis (p < 0.001). Intervention type, university as sponsor and study registration prior to completion were factors that influenced the time to publication, using Cox regression (p < 0.001).ConclusionsThis study underscores the importance of timely and accurate publication and dissemination of trial results, in order to avoid the potential waste of resources and to ensure research integrity and patient safety. We suggest that authors and journal editors adhere to conditions set out by the International Committee of Medical Journal Editors and that more diligent data sharing is encouraged through prospective trial registration and trial reporting websites. (shrink)

The boldest and most unsettling of the major early modern philosophers, Spinoza, had a much greater, if often concealed, impact on the international intellectual scene and on the early Enlightenment than philosophers, historians, and political theorists have conventionally tended to recognize. Europe-wide efforts to prevent the reading public and university students learning about Spinoza, the man and his work, in the years immediately after his death in 1677, dominated much of his early reception owing to the revolutionary implications of his (...) thought for philosophy, religion, practical ethics and lifestyle, Bible criticism, and political theory. Nevertheless, contrary to what has sometimes been maintained, his general impact was immediate, very widespread, and profound. One of the main objectives of the book is to show how early and how deeply Leibniz, Bayle, Arnauld, Henry More, Anne Conway, Richard Baxter, Robert Boyle, Henry Oldenburg, Pierre-Daniel Huet, Richard Simon, and Nicholas Steno, among many others, were affected by and led to wrestle with his principal ideas. (shrink)

My subject on this occasion goes uneasily with my piety. Lordship did not as such much interest my teachers William E. Lunt and Joseph R. Strayer, who were leaders in their turn of the Medieval Academy of America. In their presidential addresses of 1954 and 1968 both scholars dealt magisterially with subjects each had studied for forty years. Lunt spoke on financial relations of the papacy with England, Strayer on the place of Normandy and Languedoc in the building of an (...) administrative monarchy in France. It is easy to see that in a considerable sense both historians were working on medieval government, and it is some measure of their achievement that even today no one wishing to be informed in this grand subject can do much better than read Lunt and Strayer. I wish I could discourse on my own years of research as did those admirable scholars. If I cannot, it is not simply because I lack the accumulated erudition to reflect summarily on my work; it is also because I lack the conceptual serenity of my teachers in our common subject matter. Like Lunt and Strayer I have worked on justice, finance, and the beginnings of parliamentary life in the twelfth and thirteenth centuries; unlike those mentors I became uneasy about the paradigm in which these studies were framed. I came to wonder how Strayer could have held students, myself included, spellbound with details about the deportment of judges or sergeants while saying nothing about the adequacy of concepts like “government” or “administration” to describe such behavior. Believing there was something timeless about the action of people in power, he was gifted at evoking the ways of modern bureaucrats in those “corridors of power” he knew from his own experience in Washington. He assumed with other historians of his day and ours that all societies have governments, so that he could speak of feudalism as essentially a “method of government,” of “political organization … reduced to the simplest possible terms.”. (shrink)

Série de l’ère #MeToo, I May Destroy You de Michaela Coel montre que la violence est une potentialité inhérente à la relation sexuelle. Le viol n’est pas le problème spécifique de la série, mais plutôt le cas extrême et paradigmatique qui donne lieu à une problématisation plus générale de la sexualité ordinaire, en une famille de cas hétérogènes. Le point culminant de la série est la manière dont elle transmue le genre du « Rape and Revenge », en substituant à (...) la vengeance des formes politiques d’action, par la puissance du récit et de la parole publique. (shrink)

Grounding is often glossed as metaphysical causation, yet no current theory of grounding looks remotely like a plausible treatment of causation. I propose to take the analogy between grounding and causation seriously, by providing an account of grounding in the image of causation, on the template of structural equation models for causation.

According to a line of thought tracing from Descartes, Leibniz, and Locke through to Kripke, Levine, and Chalmers, there is a special explanatory gap arising between the physical and the phenomenal. I argue that the physical-phenomenal gap is not special but rather that such gaps are pervasive, lurking in the transition from the physical to the chemical and in every concrete transition from more to less fundamental. Correlatively, I argue that such gaps are unproblematic, so long as they are bridged (...) by substantive principles of metaphysical grounding. So I articulate a form of physicalism — “ground physicalism” — on which the physical grounds the chemical, the biological, and the psychological, and explain how ground physicalism resolves explanatory gap worries. (shrink)

In debates about animal sentience, the precautionary principle is often invoked. The idea is that when the evidence of sentience is inconclusive, we should “give the animal the benefit of the doubt” or “err on the side of caution” in formulating animal protection legislation. Yet there remains confusion as to whether it is appropriate to apply the precautionary principle in this context, and, if so, what “applying the precautionary principle” means in practice regarding the burden of proof for animal sentience. (...) Here I construct a version of the precautionary principle tailored to the question of animal sentience together with a practical framework for implementing it. I explain and defend the key features of this framework, argue that it is well-aligned with current practice in animal welfare science, and consider and reject a number of influential counterarguments to the use of precautionary reasoning in this area. (shrink)

What is the relation between material objects and spacetime regions? Supposing that spacetime regions are one sort of substance, there remains the question of whether or not material objects are a second sort of substance. This is the question of dualistic versus monistic substantivalism. I will defend the monistic view. In particular, I will maintain that material objects should be identified with spacetime regions. There is the spacetime manifold, and the fundamental properties are pinned directly to it.

How should one understand knowledge-wh ascriptions? That is, how should one understand claims such as ‘‘I know where the car is parked,’’ which feature an interrogative complement? The received view is that knowledge-wh reduces to knowledge that p, where p happens to be the answer to the question Q denoted by the wh-clause. I will argue that knowledge-wh includes the question—to know-wh is to know that p, as the answer to Q. I will then argue that knowledge-that includes a contextually (...) implicit question. I will conclude that knowledge is a question-relative state. Knowing is knowing the answer, and whether one knows the answer depends (in part) on the question. (shrink)

Are the sparse properties drawn from all the levels of nature, or only the fundamental level? I discuss the notion of sparse property found in Armstrong and Lewis, show that there are tensions in the roles they have assigned the sparse properties, and argue that the sparse properties should be drawn from all the levels of nature.

Extant counterfactual accounts of causation (CACs) still cannot handle preemptive causation. I describe a new variety of preemption, defend its possibility, and use it to show the inadequacy of extant CACs. Imagine that it is a law of nature that the first spell cast on a given day match the enchantment that midnight.

Are colors relational or non-relational properties of their bearers? Is red a property that is instantiated by all and only the objects with a certain intrinsic (/non-relational) nature? Or does an object with a particular intrinsic (/non-relational) nature count as red only in virtue of standing in certain relations - for example, only when it looks a certain way to a certain perceiver, or only in certain circumstances of observation? In this paper I shall argue for the view that color (...) properties are relational (henceforth, relationalism), and against the view that colors are not relational (henceforth, anti- or non-relationalism). (shrink)

This paper will articulate and defend a novel theory of epistemic justification; I characterize my view as the thesis that justification is potential knowledge . My project is an instance of the ‘knowledge-first’ programme, championed especially by Timothy Williamson. So I begin with a brief recapitulation of that programme.

Conciliatory views of disagreement maintain that discovering a particular type of disagreement requires that one make doxastic conciliation. In this paper I give a more formal characterization of such a view. After explaining and motivating this view as the correct view regarding the epistemic significance of disagreement, I proceed to defend it from several objections concerning higher-order evidence (evidence about the character of one's evidence) made by Thomas Kelly (2005).

Causal claims are context sensitive. According to the old orthodoxy (Mackie 1974, Lewis 1986, inter alia), the context sensitivity of causal claims is all due to conversational pragmatics. According to the new contextualists (Hitchcock 1996, Woodward 2003, Maslen 2004, Menzies 2004, Schaffer 2005, and Hall ms), at least some of the context sensitivity of causal claims is semantic in nature. I want to discuss the prospects for causal contextualism, by asking why causal claims are context sensitive, what they are sensitive (...) to, and where they are sensitive to it. (shrink)

Does what you know depend on what is at stake for you? That is, is the knowledge relation sensitive to the subject’s practical interests? Subject sensitive invariantists (Fantl and McGrath, 2002; Hawthorne, 2004, ch. 4; Stanley, forthcoming) say that the answer is yes. They claim to capture the contextualist data without the shifty semantics. I will argue that the answer is no. The knowledge relation is sensitive to what is in question for the attributor, rather than what is at stake (...) for the subject. There is no substitute for the contextualist semantics. (shrink)

Negative causation occurs when an absence serves as cause, effect, or causal intermediary. Negative causation is genuine causation, or so I shall argue. It involves no physical connection between cause and effect. Thus causes need not be physically connected to their effects.

A tropel is a particular property: the redness of a rose, the roundness of the moon. It is generally supposed that tropes are individuated by primitive quantity: this redness, that roundness. I argme that the trope theorist is far better served by individuating tropes by spatiotemporal relation: here redness, there roundness. In short, tropes are not this-suches but here-suches.

Three claims are widely held and individually plausible, but jointly inconsistent: (1) Negative actions (intentional omissions, refrainments, etc.) are genuine actions; (2) All actions are events; (3) Some, and perhaps all, negative actions aren't events, but absences thereof (when I omit to raise my arm, no omission-event occurs; what happens is just that no arm-raising occurs). Drawing on resources from metaphysics and the philosophy of language, I argue that (3) is false. Negative actions are events, just as ordinary actions are. (...) Moreover, each token negative action is identical to a token positive event, so we can adopt this realist view of negative actions without adding metaphysically negative entities (absences, negative states of affairs) to our ontology. (shrink)

This article is a selective review of David Lewis's Counterfactuals, a challenging, provocative, absorbingly interesting attempt to analyze statements of the form “If it were the case that P, then it would be the case that Q.” I shall follow Lewis in calling these “counterfactuals,” and shall nearly follow him in abbreviating them to the form P→Q.Chapter 1, which is nearly a third of the whole, gives the analysis and proves that it endows counterfactuals with some properties which they evidently (...) do have. Chapter 2 presents some “alternative formulations” of the analysis—a logical jeu d'esprit which I shall not discuss except for the section about “cotenability.”. (shrink)

According to a simple form of consequentialism, we should base decisions on our judgments about their consequences for achieving our goals. Our goals give us reason to endorse consequentialism as a standard of decision making. Alternative standards invariably lead to consequences that are less good in this sense. Yet some people knowingly follow decision rules that violate consequentialism. For example, they prefer harmful omissions to less harmful acts, they favor the status quo over alternatives they would otherwise judge to be (...) belter, they provide third-party compensation on the basis of the cause of an injury rather than the benefit from the compensation, they ignore deterrent effects in decisions about punishment, and they resist coercive reforms they judge to be beneficial. I suggest that nonconsequentialist principles arise from overgeneralizing rules that are consistent with consequentialism in a limited set of cases. Commitment to such rules is detached from their original purposes. The existence of such nonconsequentialist decision biases has implications for philosophical and experimental methodology, the relation between psychology and public policy, and education. (shrink)

Mammalian placental pregnancy is a neglected problem case for theories of organismality. This example is closer to home than those typically discussed within philosophy of biology. I apply evolutio...

There is nothing in this World constant but Inconstancy. [Swift 1711: 258] In this paper I argue that two standard characterizations of colour constancy are inadequate to the phenomenon. This inadequacy matters, since, I contend, philosophical appeals to colour constancy as a way of motivating illumination-independent conceptions of colour turn crucially on the shortcomings of these characterizations. After critically reviewing the standard characterizations, I provide a novel counterfactualist understanding of colour constancy, argue that it avoids difficulties of its traditional rivals, (...) and defend it from objections. Finally, I show why, on this improved understanding, colour constancy does not have the philosophical consequences that have been claimed for it in the literature. (shrink)

Knowledge ascriptions are contrast-sensitive. One natural explanation for this is that the knowledge relation is contrastive ( s knows that p rather than q ). But can the binary view of knowledge ( s knows that p ) explain contrast-sensitivity? I review some of the linguistic data supporting contrast-sensitivity, and critique the three main binary explanations for contrast-sensitivity. I conclude that the contrast-sensitivity of knowledge ascriptions shows that knowledge is a contrastive relation.

A prominent objection to non-cognitive moral bio-enhancements is that they would compromise the recipient’s ‘freedom to fall’. I begin by discussing some ambiguities in this objection, before outlining an Aristotelian reading of it. I suggest that this reading may help to forestall Persson and Savulescu’s ‘God-Machine’ criticism; however, I suggest that the objection still faces the problem of explaining why the value of moral conformity is insufficient to outweigh the value of the freedom to fall itself. I also question whether (...) the objection is compatible with Neil Levy’s parity principle. Accordingly, I go on to consider an alternative relational freedom-based objection to NCMBEs that aims to explain the fundamental moral importance of the freedom that NCMBEs would violate. I argue that although this strategy might allow the critic of NCMBEs to bypass a powerful criticism of Harris’ objection, it also weakens the freedom-based objection’s compatibility with the parity principle. (shrink)

In order for Herman Cappelen to argue in his Philosophy Without Intuitions that philosophers have been on the whole mistaken in thinking that we actually use intuitions much at all in our first-order philosophizing, he must attempt the task of characterizing what something must be, in order to be an intuition.My discussion here is focused on the latter half of the book concerning the “argument from philosophical practice. I am in wholehearted agreement with the first half’s thesis that the usage (...) of the term “intuition” is highly motley and of no methodological use. I truly sympathize with the frustration he evidently feels at wrangling with that task, because I’ve felt the same in my own project critiquing what I do take to be a fairly common practice in contemporary philosophy that we often gesture at when we speak of intuitions. For the literature on intuitions can be a total mess on even the most basic questions about what intuitions are: beliefs, or sui generis seemings? Special in .. (shrink)

Lawrence Kohlberg slayed the two dragons of twentieth-century psychology—behaviorism and psychoanalysis. His victory was a part of the larger cognitive revolution that shaped the world in which all of us study psychology and education today. But the cognitive revolution itself was modified by later waves of change, particularly an ‘affective revolution’ that began in the 1980s and an ‘automaticity revolution’ in the 1990s. In this essay I trace the history of moral psychology within the broader intellectual trends of psychology and (...) I explain why I came to believe that moral psychology had to change with the times. I explain the origins of my own social intuitionist model and of moral foundations theory. I offer three principles that I think should characterize moral psychology in the twenty-first century: (1) Intuitions come first, strategic reasoning second, (2) There’s more to morality than harm and fairness and (3) Morality binds and blinds. (shrink)

Davidson's account of weakness of will dependsupon a parallel that he draws between practicaland theoretical reasoning. I argue that theparallel generates a misleading picture oftheoretical reasoning. Once the misleadingpicture is corrected, I conclude that theattempt to model akratic belief on Davidson'saccount of akratic action cannot work. Thearguments that deny the possibility of akraticbelief also undermine, more generally, variousattempts to assimilate theoretical to practicalreasoning.

An infuential twenty-first century philosophical project posits a central role for knowledge: knowledge is more fundamental than epistemic states like belief and justification. So-called “knowledge first” theorists find support for this thought in identifying central theoretical roles for knowledge. I argue that a similar methodology supports a privileged role for more specific category of basic knowledge. Some of the roles that knowledge first theorists have posited for knowledge generally are better suited for basic knowledge.

in the treatise, hume claims to identify many “fictions of the imagination” among both “vulgar” and philosophical beliefs. To name just a few, these include the fiction of one aggregate composed of many parts,1 the fiction of a material object’s identity through change, and the fiction of a human mind’s identity through change and interruption in its existence. Hume claims that these fictions and others like them are somehow defective: in his words, they are “improper,” “inexact,” or not “strict”. I (...) will argue that this claim conflicts with other commitments.. (shrink)

It is often assumed that, while ordinary actions are events, ‘negative actions’ are absences of events. I claim that a negative action is an ordinary, ‘positive’ event that plays a certain role. I argue that my approach can answer standard objections to the identity of negative actions and positive events.

One key aim of Grafen’s Formal Darwinism project is to formalize ‘modern biology’s understanding and updating of Darwin’s central argument’. In this commentary, I consider whether Grafen has succeeded in this aim.

What kind of a thing are chronic diseases? Are they objects, bundles of signs and symptoms, properties, processes, or fictions? Rather than using concept analysis—the standard approach to disease in the philosophy of medicine—to answer this metaphysical question, I use a bottom-up, inductive approach. I argue that chronic diseases are bodily states or properties—often dispositional, but sometimes categorical. I also investigate the nature of related pathological entities: pathogenesis, etiology, and signs and symptoms. Finally, I defend my view against alternate accounts (...) of the nature of disease. (shrink)

(Tye 2006) presents us with the following scenario: John and Jane are both stan- dard human visual perceivers (according to the Ishihara test or the Farnsworth test, for example) viewing the same surface of Munsell chip 527 in standard conditions of visual observation. The surface of the chip looks “true blue” to John (i.e., it looks blue not tinged with any other colour to John), and blue tinged with green to Jane.¹ Tye then in effect poses a multiple choice question.

This paper attempts to reconcile critics and defenders of inclusive fitness by constructing a synthesis that does justice to the insights of both. I argue that criticisms of the regression-based version of Hamilton’s rule, although they undermine its use for predictive purposes, do not undermine its use as an organizing framework for social evolution research. I argue that the assumptions underlying the concept of inclusive fitness, conceived as a causal property of an individual organism, are unlikely to be exactly true (...) in real populations, but they are approximately true given a specific type of weak selection that Hamilton took, on independent grounds, to be responsible for the cumulative assembly of complex adaptation. Finally, I reflect on the uses and limitations of “design thinking” in social evolution research. The debate about the foundations of inclusive fitness theory that has followed in the wake of Nowak, Tarnita and Wilson’s (1) critique has been remarkably polarizing. After several rounds of rebuttals and replies, there is still little evidence of any serious reconciliation between the theory’s critics (2-10) and its defenders (11-24). It doesn’t have to be this way. I believe that, on the main points of disagreement, it is possible to find a way forward that does justice to the insights of both camps. My aim in this paper is to find that way forward. (shrink)

A large part of the controversy surrounding the publication of DSM-5 stems from the possibility of replacing the purely descriptive approach to classification favored by the DSM since 1980. This paper examines the question of how mental disorders should be classified, focusing on the issue of whether the DSM should adopt a purely descriptive or theoretical approach. I argue that the DSM should replace its purely descriptive approach with a theoretical approach that integrates causal information into the DSM’s descriptive diagnostic (...) categories. The paper proceeds in three sections. In the first section, I examine the goals (viz., guiding treatment, facilitating research, and improving communication) associated with the DSM’s purely descriptive approach. In the second section, I suggest that the DSM’s purely descriptive approach is best suited for improving communication among mental health professionals; however, theoretical approaches would be superior for purposes of treatment and research. In the third section, I outline steps required to move the DSM towards a hybrid system of classification that can accommodate the benefits of descriptive and theoretical approaches, and I discuss how the DSM’s descriptive categories could be revised to incorporate theoretical information regarding the causes of disorders. I argue that the DSM should reconceive of its goals more narrowly such that it functions primarily as an epistemic hub that mediates among various contexts of use in which definitions of mental disorders appear. My analysis emphasizes the importance of pluralism as a methodological means for avoiding theoretical dogmatism and ensuring that the DSM is a reflexive and self-correcting manual. (shrink)

Since its earliest incarnations, just war theory has included the requirement that war must be initiated and waged by a legitimate authority. However, while recent years have witnessed a remarkable resurgence in interest in just war theory, the authority criterion is largely absent from contemporary discussions. In this paper I aim to show that this is an oversight worth rectifying, by arguing that the authority criterion plays a much more important role within just war theorising than is commonly supposed. As (...) standardly understood, the authority criterion provides a necessary condition for the justification of the resort to war, but has no bearing on the question of permissible conduct in war. In opposition, I argue for an alternative interpretation of the criterion, which attributes to it a fundamental role in assessing this latter question. With this revised interpretation in place, I then demonstrate its advantages by applying it to the practical issue of armed conflicts that are initiated and fought by non-traditional belligerents. While several theorists have recognised that this common feature of modern armed conflict poses a challenge to mainstream just war theory in general—and to the authority criterion in particular—I argue that existing discussions frequently misconstrue the nature of the challenge, since they assume the standard interpretation of the authority requirement and its role within the theory. I then show that the revised interpretation provides a clearer account of both the challenge posed by non-traditional belligerency and the kind of response that it requires. (shrink)

Elliott Sober has recently argued that the cosmological design argument is unsound, since our observation of cosmic fine-tuning is subject to an observation selection effect (OSE). I argue that this view commits Sober to rejecting patently correct design inferences in more mundane scenarios. I show that Sober's view, that there are OSEs in those mundane cases, rests on a confusion about what information an agent ought to treat as background when evaluating likelihoods. Applying this analysis to the design argument shows (...) that our observation of fine-tuning is not rendered uninformative by an OSE. Design and the Anthropic Objection Previous responses to the Anthropic Objection Variations: experimental squads and survivor reunions Why there is no OSE in firing squad cases Application to the design argument. (shrink)

Introduction: Clinical practice guidelines (CPGs) are an important source of justification for clinical decisions in modern evidence-based practice. Yet, we have given little attention to how they argue their evidence. In particular, how do CPGs argue for treatment with long-term medications that are increasingly prescribed to older patients? Approach and rationale: I selected six disease-specific guidelines recommending treatment with five of the medication classes most commonly prescribed for seniors in Ontario, Canada. I considered the stated aims of these CPGs and (...) the techniques employed towards those aims. Finally, I reconstructed and logically analysed the arguments supporting recommendations for pharmacotherapy. Analysis: The primary function of CPGs is rhetorical, or persuasive, and their means of persuasion include both a display of their credibility and their argumentation. Arguments supporting pharmacotherapy recommendations for the target population follow a common inductive pattern: statistical generalization from randomized controlled trial (RCT) and meta-analysis evidence. Two of the CPGs also argue their treatment recommendations for older patients in this style, while three fail to justify pharmacotherapy specifically for the older population. Discussion: The arguments analysed lack the auxiliary assumptions that would warrant making a generalization about the clinical effectiveness of medications for the older population. Guidelines reason using simple induction, while ignoring important inferential gaps. Future guidelines should aspire to be well-reasoned rather than simply evidence-based; argue from a plurality of evidence; be wary of hasty inductions; appropriately limit the scope of their recommendations; and avoid making law-like, prescriptive generalizations. (shrink)

Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in ‘gene-drive’ technology have raised the prospect of eradicating certain species of mosquito via genetic modification. This technology has attracted a great deal of media attention, and the idea of using gene-drive technology to eradicate mosquitoes has been met with criticism in the public domain. In this paper, I shall dispel two moral objections that have been (...) raised in the public domain against the use of gene-drive technologies to eradicate mosquitoes. The first objection invokes the concept of the ‘sanctity of life’ in order to claim that we should not drive an animal to extinction. In response, I follow Peter Singer in raising doubts about general appeals to the sanctity of life, and argue that neither individual mosquitoes nor mosquitoes species considered holistically are appropriately described as bearing a significant degree of moral status. The second objection claims that seeking to eradicate mosquitoes amounts to displaying unacceptable degrees of hubris. Although I argue that this objection also fails, I conclude by claiming that it raises the important point that we need to acquire more empirical data about, inter alia, the likely effects of mosquito eradication on the ecosystem, and the likelihood of gene-drive technology successfully eradicating the intended mosquito species, in order to adequately inform our moral analysis of gene-drive technologies in this context. (shrink)